Businessman and businesswoman working together to protect clients confidential information and cyber security microsoft 365 defender

Best security practices with Microsoft 365 Defender to strengthen protection in our organization.

Data and system security is vital for any organization in today’s digital era. With the constant increase in cyber threats, it is essential to implement robust security solutions to protect digital assets. Microsoft 365 Defender has become a comprehensive security suite that effectively addresses these challenges.

In this article, we will explore the best security practices with Microsoft 365 Defender to strengthen protection in our organization.

What is Microsoft 365 Defender?

Microsoft 365 Defender

Microsoft 365 Defender is a comprehensive security suite designed to protect enterprise environments from cyber threats. It combines Microsoft security solutions into a unified platform, providing advanced threat protection in email, devices, and cloud applications.

Why is it important to adopt good security practices?

¿Por qué es importante adoptar buenas prácticas de seguridad? Microsoft Defender 365

In the current digital environment, protecting digital assets is a top priority for businesses. Digital assets, such as confidential data, intellectual property, and financial information, are vulnerable to various cyber threats. It is crucial to implement strong security measures to ensure their protection.

The reality is that cybercriminals are constantly evolving and perfecting their attack techniques. These include sophisticated phishing attacks, destructive ransomware, and massive data breaches. These threats can cause significant financial damage, reputation loss, and operational disruptions. Taking steps to protect against these threats and mitigate their negative impacts is crucial.

That’s why adopting best security practices has become absolutely crucial. These practices provide a proactive and strategic approach to ensure the protection of digital assets. Implementing effective security measures is key for organizations to minimize risks and mitigate potential negative impacts of cyber attacks.

What features does MICROSOFT 365 DEFENDER offer?

Microsoft 365 Defender offers a variety of advanced security features, including:

  • Advanced Threat Protection (ATP): Identifies and blocks malicious emails, such as phishing links or infected attachments. For example, if an employee receives an email with a malicious link attempting to steal confidential information, Microsoft 365 Defender will detect and block it, preventing potential security breaches.
  • Endpoint Detection and Response (EDR): Monitors and responds to suspicious behaviors and malicious activities on endpoints. Microsoft 365 Defender sends real-time alerts for signs of abnormal activity, such as unauthorized access attempts or modifications to critical files. This allows for a quick response to minimize the impact of an attack.
  • Email and Collaboration Protection: Protects your organization against email threats, such as phishing attacks and malware. It uses advanced machine learning technology to identify and block suspicious emails. For example, if an employee receives an email that appears to be from a bank entity and requests confidential information, Microsoft 365 Defender identifies and blocks the email before it reaches the user’s inbox, preventing potential security risks.
  • Security Monitoring and Analysis: Provides intuitive dashboards and analysis tools. These tools allow you to monitor and analyze the security posture of your organization. For example, you can identify threat patterns, analyze security incidents, and generate detailed reports on the performance of security in your Microsoft 365 environment. This information will help you make more informed decisions to strengthen your security posture and protect your business assets.

The features of Microsoft 365 Defender provide comprehensive and proactive defense against security threats. This ensures the protection of your data and the continuity of your business operations.

How to configure MICROSOFT 365 DEFENDER correctly?

Cómo configurar Microsoft 365 defender

To configure Microsoft 365 Defender correctly and ensure effective protection, follow these steps:

Requirements Evaluation:

Before starting the configuration, it is important to assess the specific security requirements of your organization. Identify critical digital assets that need to be protected, necessary security policies, and compliance needs. This will help you define configuration objectives.

Deployment Planning:

When configuring Microsoft 365 Defender, create a detailed deployment plan. This plan should establish the steps and proper sequence to ensure effective configuration. Consider resource allocation, task scheduling, and communication with relevant teams. This will ensure a smooth and successful implementation of Microsoft 365 Defender.

Security Service Activation:

Verify that the required security services are activated in your Microsoft 365 subscription. Make sure to activate Microsoft Defender for Endpoints, Office 365 Advanced Threat Protection (ATP), Microsoft Defender for Office 365, and Microsoft Defender for Identity. Activating these services is essential to strengthen security and protect your systems and data.

Security Policy Configuration:

Define and configure custom security policies that align with your organization’s requirements. Include policies for protection against malware, phishing, spam, and access to files and cloud applications. For example, establish a blocking policy for suspicious email attachments in incoming emails.

Alerts and Notifications Configuration:

Set up real-time alerts and notifications for important security events. Configure alerts according to the priority and criticality of incidents to ensure proper attention. For example, configure alerts to detect unauthorized login attempts or suspicious activities on endpoints.

Integration with Other Security Services:

Microsoft 365 Defender integrates with other Microsoft security services, such as Azure Sentinel and Microsoft Defender for Identity. Configure the necessary integrations to obtain a holistic view of security and enable more effective detection and response. For example, configure integration with Azure Sentinel for advanced threat analytics.

Continuous Monitoring and Maintenance:

Configuring Microsoft 365 Defender is an ongoing process. Continuously monitor security events, analyze reports and metrics, and make periodic adjustments to maintain and improve the security posture of the organization. Perform regular updates and stay informed about the latest features and best security practices of Microsoft

Remember that each organization has specific needs and requirements, so it is important to adapt these steps to your environment. Consult official Microsoft documentation and seek expert advice for optimal configuration of Microsoft 365 Defender in your organization.

How to prevent common threats?

¿como evitar las amenazas mas comunes Microsoft 365 Defender

Among all the threats within an organization, the most common ones often originate from email or cloud applications (such as Microsoft Teams, SharePoint, OneDrive). Here are some practical and specific tips to prevent these threats:


  • Staff Awareness and Training: Educate employees about the risks of phishing and other email attacks. Emphasize the importance of verifying spelling and grammar in suspicious emails and avoid providing confidential information in response to unsolicited emails. For example, never send confidential information like passwords or credit card numbers via email.
  • Sender and URL Verification: Before opening any email or clicking on links, verify the authenticity of the sender and URL. Be cautious of unknown or suspicious senders. Always verify that links come from trusted sources and avoid clicking on shortened or suspicious links.
  • Caution with Attachments and Links: Avoid opening attachments or clicking on links in unsolicited or suspicious emails. Always verify the source and use security solutions to scan attachments for potential threats. Additionally, never download or run attachments that appear suspicious or unexpected.

Cloud Applications:

  • Compliance Policy Implementation: Implement compliance policies in cloud applications to ensure compliance with relevant security regulations and standards. This involves establishing strong security policies, such as multifactor authentication (MFA), to protect access to data stored in the cloud.
  • Permission and Role Management: Establish appropriate permission structures to ensure that only authorized users have access to sites and documents in cloud applications. Regularly review and update permissions based on organizational needs, revoking access for users who no longer require it.
  • Regular Backups: Perform regular backups of data stored in cloud applications to protect against information loss. Ensure you have a data recovery plan in case of security incidents or system failures. Additionally, verify that data retention policies are properly configured to comply with legal and business requirements.

By following these tips, you can strengthen your organization’s security and reduce the risk of falling victim to common threats in email and cloud applications. Remember that continuous awareness and updating of security measures are essential to maintain protection in an ever-evolving environment. Keep your staff informed about the latest attack techniques and promote a culture of security throughout the organization.

In conclusion…

Adopting best security practices with Microsoft 365 Defender becomes crucial to protect digital assets and safeguard the integrity of an organization in an increasingly complex cyber environment. By implementing the advanced features of Microsoft 365 Defender, such as threat protection, endpoint detection and response, and email and collaboration security, we can significantly strengthen our security posture.

By properly configuring Microsoft 365 Defender, customizing security policies, training employees, and maintaining constant monitoring, we ensure staying one step ahead of constantly evolving cyber threats. Additionally, by avoiding common threats like phishing and vulnerabilities in cloud applications, we can reduce the risk of security incidents and safeguard the confidentiality, integrity, and availability of our data.

By adopting these best security practices with Microsoft 365 Defender, we are strengthening our ability to efficiently respond to and mitigate cyber attacks, thereby protecting our reputation, preventing operational disruptions, and ensuring the trust of our customers and partners.

Ultimately, investing in a solid security infrastructure and following best practices with Microsoft 365 Defender allows us to not only protect our digital assets but also drive the continued growth and success of our organization in the ever-evolving digital world.

To learn more about how to protect your business with Microsoft Intune and Defender, contact us. Protect your business and take advantage of the benefits of a market-leading security solution.

Enric Robert – Software Technician at Itequia